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Themed collection Coronavirus articles - free to access collection

156 items - Showing page 1 of 3
Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

玛戈特·瓦尔斯特伦在20多岁时结束了一段充满暴力的感情。作为外交部长,她正在一个传统上属于男性的领域里挑战各种假定。
新上榜品牌有26个,其中前三名为乐视、安邦和东方财富,其中民营品牌占70%。小米品牌价值涨幅最大,其价值是去年五倍,为73亿美元,TCL和华为位居其后。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

家用电器行业的平均价值上升了74%,是10大行业里上升幅度最大的。电子商务和零售业位居其后,价值上涨了69%。医疗卫生保健行业上升32%。金融服务行业上升了18%,酒类行业上升了17%。房地产增长了15%,饮食行业上升了11%。
The only thing worse than being bad is being bad without a vision. Johnson never lacked vision as a player and he's off to a good start as an executive.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 湖北将加强房地产市场调控
Open Access Perspective

Soft matter science and the COVID-19 pandemic

There are lots of benefits to studying in a group. You have to be organized. You can't procrastinate. You have to really understand something to be able to explain it out loud to someone else.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

萝丝王在中国长大,在那里学会了计算机编程。大学毕业后,她希望到美国工作。第二年,《中国学生保护法案》(Chinese Students Protection Act)获得通过,萝丝王获得了休斯敦大学的计算机科学硕士学位。2001年9月11日之前,她曾在多家硅谷初创公司(包括成立自己的公司iBizWomen.com)工作。911事件让她产生了创办Binary Group的想法。Binary Group是一家与联邦政府合作的科技咨询公司。过去16年间,这家公司帮助客户节省的资金不计其数——比如美军第20支援司令部(Army 20th Support Command)就在五年时间内共节省了6,000万美元卫星通信带宽开支。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

'She does wear wigs and crowns and fancy dresses but I don't give her spray tans or cake her in makeup - I'll wait until she's about five for that.'
Usher “Good Kisser” (RCA)
China has continued to synchronize enterprises and institutions to raise the basic pension for over 100m retirees in 2017.
Do not forget why you're attending these conferences, who you're doing this for -- we are your own children. You are deciding what kind of world we will grow up in. Parents should be able to comfort their children by saying "everyting's going to be alright" , "we're doing the best we can" and "it's not the end of the world". 不要忘记你们为何而来到这里开会,你们为谁做事情?我们是你们的下一代,你们正在决定我们将要在一个什么样的环境中成长,父母需要能够宽慰孩子们,告诉他们“一切都没问题,那不是世界末日,我们正在尽其所能的改变”。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Will Smith had a very successful career in the late 80s and early 90s as the second half of rap duo DJ Jazzy Jeff and the Fresh Prince. But in spite of his financial success, Smith did not manage his money well. It's a pretty classic tale, really. New fame, lots of money, no future plans, and lots of fancy toys added up to a lot of overspending. This lack of oversight and fiscal irresponsibility landed him on the brink of bankruptcy. He owed the government back taxes that he had not paid.
纽约人向专栏提出的问题,不仅取决于他们的个人情况,还取决于当今的重大问题,比如住房成本上升、士绅化、豆腐渣工程。最终,2014年成为了一个一切都在增长的年份,增长的包括房价、租金,以及最重要的——楼盘数量。根据纽约房地产委员会(Real Estate Board of New York)的数据,10月批准建设的单元达到了16700套。
3) Tell Me More: “I’m all ears.” It’s the ultimate conversation starter! When you signal that you’re open and intrigued, the other party will respond in kind. And who can resist flattery? If your interest is genuine, you may just fuel a productive exchange.
Celebuzz has pulled together some of the best snaps of celebrities who go pumpkin picking.Have a look now in the gallery above, then tell us: Are you ready to celebrate Halloween on Wednesday?

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

“双随机、一公开”监管:随机抽取检查对象,随机选派执法检查人员,及时公布查处结果

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Song “Wind Blowing In The Wheat Field” (Li Jian and Sun Li)

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

Some 18.1 million people, for example, want a good full-time job but can't find one, an unusually high number 5 1/2 years into a recovery. And despite a sharp decline in the number of people out of work six months or longer, that figure is still higher than at any time before the 2007-09 recession.
D'Aloisio himself strives to maintain a bubble of normalcy. He dates the same girl he did before the whirlwind hit. And though he's stopped attending school-he's too busy to sit in class while overseeing Summly's development-he still gets his work from his teachers and meets with them regularly. He cherishes the fact that his circle of friends knows little of his life as a budding industrialist. When I met him, he was about to head to Greece for a weeklong vacation with a pack of high school pals.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 川渝家居建材卖场加速扩容
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.
3The United Kingdom

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

《体育画报》泳装专刊模特凯特·阿普顿位于2015全球美女榜第八。这位时尚名模去年曾是本榜单亚军。今年她也入选了《人物》杂志最性感女性榜单。
74个重点城市细颗粒物(PM2.5)年均浓度下降9.1%;

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

We were all going direct to Heaven, we were all going direct the other way
We will improve planning for regional development.
碧昂丝vs. 珍妮弗·洛佩兹
尽管詹姆斯和费德勒在工资和薪水上要少一些(相比于C罗和梅西),但是这两人去年的代言费是最高的,其中17次大满贯得主费德勒去年代言收入达到了4100万英镑。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

汤姆汉克斯和梅丽尔斯特里普出演,史蒂文斯皮尔伯格执导,这样一个为新闻自由而战的历史故事,有很多让评委刮目相看的地方。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

The web portal, which has put mobile technology at the heart of a plan to turn around its struggling fortunes, has turned to British teenager Nick D’Aloisio and Summly, which automatically summarises news stories for the small screen.
推特方面日前表示,在今年8月弗吉尼亚州夏洛特维尔爆发种族骚乱后,奥巴马发布的一条推文是今年转推量第2多的推文,转推量达170万次以上。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

在360000个网红账号中,女性达到74%。而87.8%的网红年龄都在17-33岁之间,89%的网红接受过高等教育。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Agriculture/forestry/husbandry/fishery and the service industry offer the lowest pay to new grads, at 3,347 and 3,115 yuan a month on average.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
The big winners over the past year in Arizona were the construction and leisure/hospitality industries, which both added more than 10, 000 jobs. Other fast-growing sectors include business services, financial activities and education and health services.
95后对就业的选择更加多元化,也更加青睐工作与兴趣相结合。
So far this year, companies have announced 376 share-repurchase initiatives for a total of $261 billion, according to data from Birinyi Associates. That's nearly 72% higher than 2012, though slightly lower when compared to the same period in 2013, which was a record year for buybacks.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

这句话最流行的变体是“别迷恋姐,姐只是个传说。”
The memes included jokes about pedophilia, child abuse, sexual assault, and the Holocaust.
该新规还专门针对出租车服务作出规定。
包括中国移动、阿里巴巴和腾讯的16家中国企业进入了该榜单的前100名。
“我们内地的执法太不严了,一帮导演到了新加坡不敢抽烟,可是到了珠海,在有警告的情况下依然抽!所以我们的执法一定要严!”

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

巴黎是前十名中唯一的欧元区国家,而且下降了3个名次,报告指出这可能是由于对欧元的信心下降。
中国台湾台东——这座连接了无人小岛三仙岛和台东县的人行桥非常有名,因为它由8座拱桥相连而成。在《孤独星球》2016年“亚洲最佳景点”中,这座沿海小县城也名列其中。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

One key thing the best bosses seem to have in common is that they are all consummate problem solvers. They can not only spot them, but brainstorm successful and innovative ways to fix them。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

让温馨的祝愿、幸福的思念和友好的祝福,在新年来到你身边,伴你左右。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 北京朝阳区不动产登记半天全搞定
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

而在进口一侧,不论以人民币还是美元计,情况都愈发糟糕。
也许经济增长率是否能达到3%的国内最大威胁是利率的突然调整,但是从各方面的预测来看鸽派的美联储在2015年不太可能会采用挑衅的利率策略。
颁奖典礼一开始,两位主持人妙语连珠,引来场下观众阵阵喝彩。马特?戴蒙、梅丽尔?斯特里普(Meryl Streep)和乔治克?鲁尼都自然而然地成为了调侃的对象。蒂娜?费对桑德拉?布洛克(Sandra Bullock)和克鲁尼参演《地心引力》的点评引发场下一阵爆笑。
1.Mitsubishi. Brand love: -12% / Rank: 360

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The potential for conflict will force China and the US to redefine their roles in a shifting environment that neither is comfortable with. Tensions will be aggravated by anti-China sentiment during the American elections. Asian countries are in a position to delineate the boundaries of influence for these two powers but, given their varied interests, alliances will shift depending on individual concerns.
Here are some of the year's pinnacles and potholes:
与此同时,最近几个月,中国内地投资者一直在迅速开设股票交易账户并将资金投入股市。上证综指已成为亚洲今年表现最佳的股指,今年迄今已累计上涨近45%。
身为欧元区较弱经济体之一的意大利,是欧盟国家中获得中国企业投资最多的。这主要归因于倍耐力(Pirelli)和中国化工(ChemChina)达成的79亿美元交易。法国排在第二位,通过旅游和基础设施行业的一系列大笔交易获得36亿美元投资。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

台湾电影无缘2012奥斯卡最佳外语片
我们要求FlightAware对航班抵达延误情况进行统计,而不是航班出发延误情况,因为有时候,航空公司可以让飞机在空中飞行期间追回地面上失去的时间。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

胡须的神奇之处
In 2016, 1,576 foreigners became permanent Chinese residents, an increase of 163% on the previous year, according the Ministry of Public Security.
“我们内地的执法太不严了,一帮导演到了新加坡不敢抽烟,可是到了珠海,在有警告的情况下依然抽!所以我们的执法一定要严!”
欧盟正明确表现出,它希望利用美国在贸易上领导力的空缺来敲定新的贸易协议。欧盟在拉丁美洲与南方共同市场(Mercosur)的谈判时断时续,已经进行了10多年。但欧盟和阿根廷等南方共同市场的关键成员国正推动在今年年底前达成一项协议。这将成为一项重要声明,正好杵在美国的后院内。
Its alumni enjoyed by far the greatest financial rewards, with an average salary of $469,000 three years after graduation.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 十三五规划不再投入LED行业补贴
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

“Australia stands out as a market that boomed when reform allowed it to switch from a commission-based model to a fee-based one,” says Mr Montanari. “This would be a game changer in Asia.”
Steven Spielberg directs Meryl Streep and Tom Hanks in The Post, a thrilling drama about the unlikely partnership between The Washington Post's Katharine Graham (Streep), the first female publisher of a major American newspaper, and editor Ben Bradlee (Hanks), as they race to catch up with The New York Times to expose a massive cover-up of government secrets that spanned three decades and four U.S. Presidents. The two must overcome their differences as they risk their careers - and their very freedom - to help bring long-buried truths to light.
"We are quite interested in looking at China's efforts and experience in combating corruption. It's a problem we are faced with in South Africa, and one we are tackling with a lot of vigor.Recently, the South African government introduced new measures to combat corruption. This is interesting, because it was immediately after a visit by our minister for public services, who met with the minister here who is responsible for anti-corruption measures.So this is one of the examples of the usefulness of this interaction between our leadership and the leadership of the People's Republic of China."

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

圣保罗报的民意调查是基于在贝洛奥里藏特(Belo Horizonte)的米内朗球场( Mineirao)对693名球迷进行的采访,统计误差为4%左右。
但是,房地产经纪公司世邦魏理仕(CBRE)香港机构投资团队主管约翰?戴维斯(John Davies)说,价格下降应会让香港房地产市场变得更加可靠。“这个市场正在显示出机构投资者更了解的成熟市场的特征,”他说。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Quanta Computer, ” in October. Samsung is also reported to be working on a 12 to 13-inch tablet, and it seems evident that “these large-size tablets will greatly impact ultrabook demand.” This “iPad Max” will be a defacto laptop with the addition of new cases with integrated keyboards and batteries and could well become a mainstay for high schools and college students who need better content creation tools than thos offers on existing iPads and iPad Minis.
as加强+soc社会+ion→社团;联合
源于:commend(v 称赞;推荐)

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

He failed to do so and Presti smartly moved on while he could still recoup some value.
Investigators have arrested one youth and one 18-year-old in connection to the July 9th shooting.
此外,排名前列的城市的“成本”、“文化与居民生活”两项指标普遍不高。在满足民众需求、并提供高质量生活方面,中国的“机遇城市”仍然面临挑战。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

随着俄罗斯货币卢布一再对其他货币贬值,近年来去往俄罗斯旅游的旅客也在逐渐增多。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

零工经济(gig economy)

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

"这是自然保护的一次伟大创举。"
Winners: Lakers

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

11. Arctic and Antarctic sea ice volumes both fall to an all-time low
乔斯的母亲因玛·克萨达在接受《西班牙日报》采访时表示,她的儿子想要给自己的乐队“Los Salerosos”(大意为“冒失鬼”)购买乐器。他在乐队里担任小号手。
It was the spring of hope, it was the winter of despair…
Harry Styles, 'Harry Styles'

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 北京家居市场版图悄然变化
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

同时,美国Rapper歌手Eminem被证明是“复出王”,摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争,包括Drake, Future, Kendrick Lamar and Post Malone。
vigor(n 精力;活力)

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

中国正考虑出售在政府补贴政策下累积的过剩储备。
In October, South Africa brought down its holdings of US government securities to USD 10.3 billion.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

Forex reserves fell $87bn in November, near the record $94bn decline suffered in August — the same month that the central bank surprised global markets by allowing the renminbi to depreciate by 3 per cent in three days.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

伊莎贝拉卡敏斯卡(Izabella Kaminska)
7.Manage up, down, and sideways
poised
vt. 打碎,破掉

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

至少希拉里今年赢得了点什么。我相信她会非常兴奋。
5. Smart belt

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

“Even though there is significant awareness [of the role of Fed policy], market dynamics can become unstable or unfavourable relatively easily,” he says. “Then you get into a self-reinforcing cycle of selling pressure.”
The parents of a number of stars have ended up with their Oscar-winning child’s awards. Angeline Jolie’s late mum, for a number of years, had the best supporting actress award her daughter won for her role as the troubled Lisa Rowe in Girl, Interrupted. Nicole Kidman’s best actress Oscar for The Hours now sits on her parents’ mantelpiece in Sydney, where neighbours apparently pass by for visits. Hollywood’s darling du jour, Jennifer Lawrence, keeps the award she won last year for her leading role in Silver Linings Playbook on top of her parents’ piano at home in Kentucky.
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资,把配置比重从两年前相对基准超配6%至8%调整至超配1%。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

不过,人们并没有对周二的峰会寄予过高期望,因为没有任何迹象表明,各国能在政治上实现突破,进而采取更有力的举措。科学家表示,要想如愿把全球变暖控制在各国五年前一致同意的上限,那么未来几年里,就必须扭转排放量上升的势头。现有的所有方案,与实现这一目标都相距甚远。
4. Mark Turner Quartet “Lathe of Heaven” (ECM) On his first proper album as a leader in 13 years, the tenor saxophonist Mark Turner favors slithery interplay with the trumpeter Avishai Cohen, and finds new purpose in post-bop protocols. There’s dry intrigue in his compositions, and supple exactitude in his rhythm team: Joe Martin on bass, Marcus Gilmore on drums.
competition

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

n. 计算
5. 《卡罗尔》,导演:托德·海因斯。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 浙江省出台办法规范“网约房”
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 打造LED光源照明工程“扮靓”合肥
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

association
英国剑桥大学Judge商学院(Judge Business School)排名上升速度最快,今年上升19位,名列第29位,这得益于其在高管MBA排名中的出色表现(该学院今年首次参与此项排名)。华威商学院(Warwick Business School)重返榜单前20名(位列第19),该校去年未参加管理硕士排名。
n. 奇思妙想,一段楼

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

印度总理纳伦德拉莫迪(Narendra Modi)会尝试更多非正统的经济试验吗?
But the struggle for white identity is not just a political problem; it is about the “deep story” of feeling stuck while others move forward.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

East Asia's cinephiles won't have a local favorite to cheer during this year's foreign-language Academy Awards race after the Taiwan epic 'Warr
除此之外,它的设计者是92岁的黄永玉大师,一位著名的画家,使它成为了极具收藏价值的物品。
The quickest growth in executive pay on average came from the hotel and catering sectors, at 47.58%.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

1. “Timbuktu”(Abderrahmane Sissako)

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 打造LED光源照明工程“扮靓”合肥
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

FOYLE’S WAR (acorn.tv, Feb. 2) After nabbing the final three episodes of “Agatha Christie’s Poirot” last year, the streaming service Acorn TV scores another coup in the field of traditional British mysteries with the American premiere of this superior show’s ninth season. Starring Michael Kitchen as Christopher Foyle, a detective as honorable as he is shrewd, the series has morphed over the years from a provincial home-front cop show to a le Carré-like Cold War thriller. New episodes involve the Nuremberg trials and Britain’s role in Palestine.
A pair of post-mumblecore comedies about self-realization and its limits. Mr. Bujalski’s is a flawless screwball triangle (with Guy Pearce, Cobie Smulders and Kevin Corrigan as the sides) masquerading as an easygoing hangout with the oddballs of Austin, Tex. Ms. Piven surveys the darker territory of mental illness and daytime television. Thanks to Kristen Wiig’s astounding performance (as a lottery winner named Alice Klieg), “Welcome to Me” is a portrait of an American dreamer that is unsettling and inspiring in equal measure.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

现在压力都在诺埃尔这里了,他得证明自己远比在76人时期迷失在混乱中的时候强。
The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

不过,最大城市的房价上涨已经放缓,比如北京录得的环比涨幅只有0.5%,大大低于9月份的4.9%。
Whenever I talk to people about the future, I'm struck by their belief that it is knowable. The impression I get is that most people imagine the future like a book ending: already written and readable if you can just steal a quick look at the last few pages. What they find difficult is accepting that the pages aren't written yet. The future hasn't happened, hasn't even been planned--and cannot be known because it doesn't exist.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

“Since these developments will not fade overnight, there is little hope for a trade revival in 2017,” says Mr Leering.
This habit can seriously hurt you in a work setting. If you’re one of those folks who believes that you do your best work at the last minute and put off projects or assignments until the day (or hour) before they’re due, you may not be aware of the impact your habit is having on your co-workers.If your last-minute rush requires others to work quickly, you will likely anger them, and you’ll be the first one blamed when a project fails or isn’t completed on time.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

['greisf?l]

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
From the themed collection: 广州:“十一”楼市一二手连连看
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

3、Negativity
5.谷歌网站管理员工具
The swap is due largely to the major security breach at software company Adobe in October which affected tens of millions of users.
n. 改进,改善

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Homeowners in neighborhoods like the Grand Concourse in the Bronx or Elmhurst in Queens could enjoy new attention from buyers eager to find the next untapped market. “When have you heard talk about Kingsbridge in the Bronx?” asked Ms. Ramirez of Halstead. “The people who are smart are getting out there and buying it up at wonderful prices.”

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

1."The Little Kicks" in Seinfeld Almost Didn't Happen
6.You Spend Time Looking For Other Jobs
会。莫迪一夜之间废除大面额纸币的做法令人震惊,严重扰乱了印度经济。但此举带来了丰厚的政治回报,支撑了莫迪作为愿意采取严厉措施打击腐败的果决领导人的形象。面临2019年的下一届大选,莫迪很有可能想拿出另一项轰动性措施来博取选民的支持。当心,他可能会对那些为了隐藏资产而以他人名义持有房产的富人采取重大行动。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

supervision
联邦、州和地方政府的裁员速度开始放缓。去年各级政府部门有逾25万人失去工作。今年截至目前,约有两万人找到了工作。经济学家说,美国的债务和赤字问题引发的担忧可能将限制政府支出和投资,但基础设施支出的任何反弹都会创造就业岗位。至少政府带来的拖累会减小。[qh]

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

At tech start-up conferences, such as Slush in Helsinki in December, everyone was talking about experiences. The coming year is likely to see a wider adoption of virtual reality, which places the user in a digitally enhanced environment, and augmented reality, which overlays digital information on to the real world, creating new digital businesses.
[tr?ns'p?:t]

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

翻译:译言网虽然面临全球经济衰退,但你依然能看到生生不息的Chanel,“我们依然非常赚钱,”Karl Lagerfeld坚定地说,他犀利的目光从墨镜后透射出来,好像这个事实就像埃

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Unless Charles Oakley successfully sues owner James Dolan, the highlight of the Knicks' 2016–17 season will be Kristaps Porzingis winning the Skills Challenge at All-Star Weekend.
在过去三年里,夏威夷航空公司的航班延误率只有6.92%,几乎是排名第二的阿拉斯加航空公司的一半——这家公司的航班延误率达到11.27%。
不久后,拉塞尔爱上了一名叫菲利普·莫里斯的狱友。莫里斯出狱后,拉塞尔通过给职员办公室打电话再次越狱,还假冒法官,大幅降低了自己的保释金。为了和莫里斯在一起,他又被捕和逃脱了两次,一度假装自己已经离世。他现在被判终身监禁,但表示看到自己的电影形象很激动。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

['regju.leit,'regjuleit]
杨金秀(Olive Yang)
The annual national civil service exam kicked off last Sunday, and some recent hot topics - such as college graduates starting their own businesses and the Yutu (Jade Rabbit) lunar rover - appeared in the exam questions.
您只需轻轻一挥将它们放飞,泡沫气球就会自己飘向空中。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

Warm greetings and best wishes for the New Year!致以热烈的祝贺和良好的祝福,新年快乐。
Consoles: Xbox One, Xbox 360

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Her mother Stephanie Boyden, 32, says Bobbi is a 'diva' who runs to the stage when her name is called - and screams when she has to leave.
summary
That comes in spite of official figures released on Tuesday showing China’s exports had contracted for a second straight month in October, suggesting domestic demand is the main driver of price gains for producers.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

n. 授予物,补助金; 同意,给予
《死侍》将于2016年2月12日爆笑上映。 当然,电影中还有不少动作和杀戮场景。

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