Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The only thing worse than being bad is being bad without a vision. Johnson never lacked vision as a player and he's off to a good start as an executive.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
There are lots of benefits to studying in a group. You have to be organized. You can't procrastinate. You have to really understand something to be able to explain it out loud to someone else.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
萝丝王在中国长大，在那里学会了计算机编程。大学毕业后，她希望到美国工作。第二年，《中国学生保护法案》（Chinese Students Protection Act）获得通过，萝丝王获得了休斯敦大学的计算机科学硕士学位。2001年9月11日之前，她曾在多家硅谷初创公司（包括成立自己的公司iBizWomen.com）工作。911事件让她产生了创办Binary Group的想法。Binary Group是一家与联邦政府合作的科技咨询公司。过去16年间，这家公司帮助客户节省的资金不计其数——比如美军第20支援司令部（Army 20th Support Command）就在五年时间内共节省了6,000万美元卫星通信带宽开支。
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
'She does wear wigs and crowns and fancy dresses but I don't give her spray tans or cake her in makeup - I'll wait until she's about five for that.'
Usher “Good Kisser” (RCA)
China has continued to synchronize enterprises and institutions to raise the basic pension for over 100m retirees in 2017.
Do not forget why you're attending these conferences, who you're doing this for -- we are your own children. You are deciding what kind of world we will grow up in. Parents should be able to comfort their children by saying "everyting's going to be alright" , "we're doing the best we can" and "it's not the end of the world". 不要忘记你们为何而来到这里开会，你们为谁做事情？我们是你们的下一代，你们正在决定我们将要在一个什么样的环境中成长，父母需要能够宽慰孩子们，告诉他们“一切都没问题，那不是世界末日，我们正在尽其所能的改变”。
Trends and targets in antiviral phototherapy
Will Smith had a very successful career in the late 80s and early 90s as the second half of rap duo DJ Jazzy Jeff and the Fresh Prince. But in spite of his financial success, Smith did not manage his money well. It's a pretty classic tale, really. New fame, lots of money, no future plans, and lots of fancy toys added up to a lot of overspending. This lack of oversight and fiscal irresponsibility landed him on the brink of bankruptcy. He owed the government back taxes that he had not paid.
纽约人向专栏提出的问题，不仅取决于他们的个人情况，还取决于当今的重大问题，比如住房成本上升、士绅化、豆腐渣工程。最终，2014年成为了一个一切都在增长的年份，增长的包括房价、租金，以及最重要的——楼盘数量。根据纽约房地产委员会(Real Estate Board of New York)的数据，10月批准建设的单元达到了16700套。
3) Tell Me More: “I’m all ears.” It’s the ultimate conversation starter! When you signal that you’re open and intrigued, the other party will respond in kind. And who can resist flattery? If your interest is genuine, you may just fuel a productive exchange.
Celebuzz has pulled together some of the best snaps of celebrities who go pumpkin picking.Have a look now in the gallery above, then tell us: Are you ready to celebrate Halloween on Wednesday?
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Song “Wind Blowing In The Wheat Field” (Li Jian and Sun Li)
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Some 18.1 million people, for example, want a good full-time job but can't find one, an unusually high number 5 1/2 years into a recovery. And despite a sharp decline in the number of people out of work six months or longer, that figure is still higher than at any time before the 2007-09 recession.
D'Aloisio himself strives to maintain a bubble of normalcy. He dates the same girl he did before the whirlwind hit. And though he's stopped attending school-he's too busy to sit in class while overseeing Summly's development-he still gets his work from his teachers and meets with them regularly. He cherishes the fact that his circle of friends knows little of his life as a budding industrialist. When I met him, he was about to head to Greece for a weeklong vacation with a pack of high school pals.
ACE2 as a potential therapeutic target for pandemic COVID-19
On our increasingly human-dominated planet we can still learn much from the lives of other species. The discovery this year that the Greenland shark lives for 400 years, making it the longest-living vertebrate, puts our hectic lives into perspective.
3The United Kingdom
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
We were all going direct to Heaven, we were all going direct the other way
We will improve planning for regional development.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The web portal, which has put mobile technology at the heart of a plan to turn around its struggling fortunes, has turned to British teenager Nick D’Aloisio and Summly, which automatically summarises news stories for the small screen.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Agriculture/forestry/husbandry/fishery and the service industry offer the lowest pay to new grads, at 3,347 and 3,115 yuan a month on average.
Antiviral drug discovery: broad-spectrum drugs from nature
The infectious disease known as scarlet fever famously reached pandemic proportions in the 19th century, striking down the young and the weak across the Western world.
The big winners over the past year in Arizona were the construction and leisure/hospitality industries, which both added more than 10, 000 jobs. Other fast-growing sectors include business services, financial activities and education and health services.
So far this year, companies have announced 376 share-repurchase initiatives for a total of $261 billion, according to data from Birinyi Associates. That's nearly 72% higher than 2012, though slightly lower when compared to the same period in 2013, which was a record year for buybacks.
Influenza neuraminidase: A druggable target for natural products
The memes included jokes about pedophilia, child abuse, sexual assault, and the Holocaust.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
One key thing the best bosses seem to have in common is that they are all consummate problem solvers. They can not only spot them, but brainstorm successful and innovative ways to fix them。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
颁奖典礼一开始，两位主持人妙语连珠，引来场下观众阵阵喝彩。马特?戴蒙、梅丽尔?斯特里普(Meryl Streep)和乔治克?鲁尼都自然而然地成为了调侃的对象。蒂娜?费对桑德拉?布洛克(Sandra Bullock)和克鲁尼参演《地心引力》的点评引发场下一阵爆笑。
1.Mitsubishi. Brand love: -12% / Rank: 360
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The potential for conflict will force China and the US to redefine their roles in a shifting environment that neither is comfortable with. Tensions will be aggravated by anti-China sentiment during the American elections. Asian countries are in a position to delineate the boundaries of influence for these two powers but, given their varied interests, alliances will shift depending on individual concerns.
Here are some of the year's pinnacles and potholes:
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
In 2016, 1,576 foreigners became permanent Chinese residents, an increase of 163% on the previous year, according the Ministry of Public Security.
Its alumni enjoyed by far the greatest financial rewards, with an average salary of $469,000 three years after graduation.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“Australia stands out as a market that boomed when reform allowed it to switch from a commission-based model to a fee-based one,” says Mr Montanari. “This would be a game changer in Asia.”
Steven Spielberg directs Meryl Streep and Tom Hanks in The Post, a thrilling drama about the unlikely partnership between The Washington Post's Katharine Graham (Streep), the first female publisher of a major American newspaper, and editor Ben Bradlee (Hanks), as they race to catch up with The New York Times to expose a massive cover-up of government secrets that spanned three decades and four U.S. Presidents. The two must overcome their differences as they risk their careers - and their very freedom - to help bring long-buried truths to light.
"We are quite interested in looking at China's efforts and experience in combating corruption. It's a problem we are faced with in South Africa, and one we are tackling with a lot of vigor.Recently, the South African government introduced new measures to combat corruption. This is interesting, because it was immediately after a visit by our minister for public services, who met with the minister here who is responsible for anti-corruption measures.So this is one of the examples of the usefulness of this interaction between our leadership and the leadership of the People's Republic of China."
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
圣保罗报的民意调查是基于在贝洛奥里藏特（Belo Horizonte）的米内朗球场（ Mineirao）对693名球迷进行的采访，统计误差为4%左右。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Quanta Computer, ” in October. Samsung is also reported to be working on a 12 to 13-inch tablet, and it seems evident that “these large-size tablets will greatly impact ultrabook demand.” This “iPad Max” will be a defacto laptop with the addition of new cases with integrated keyboards and batteries and could well become a mainstay for high schools and college students who need better content creation tools than thos offers on existing iPads and iPad Minis.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
He failed to do so and Presti smartly moved on while he could still recoup some value.
Investigators have arrested one youth and one 18-year-old in connection to the July 9th shooting.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
11. Arctic and Antarctic sea ice volumes both fall to an all-time low
It was the spring of hope, it was the winter of despair…
Harry Styles, 'Harry Styles'
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
同时，美国Rapper歌手Eminem被证明是“复出王”，摘得最佳Hip Hop歌手奖。”The Lose Yourself ”的创作者与Hip Hop的新面孔相互竞争，包括Drake, Future, Kendrick Lamar and Post Malone。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
In October, South Africa brought down its holdings of US government securities to USD 10.3 billion.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Forex reserves fell $87bn in November, near the record $94bn decline suffered in August — the same month that the central bank surprised global markets by allowing the renminbi to depreciate by 3 per cent in three days.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
7.Manage up, down, and sideways
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
5. Smart belt
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
“Even though there is significant awareness [of the role of Fed policy], market dynamics can become unstable or unfavourable relatively easily,” he says. “Then you get into a self-reinforcing cycle of selling pressure.”
The parents of a number of stars have ended up with their Oscar-winning child’s awards. Angeline Jolie’s late mum, for a number of years, had the best supporting actress award her daughter won for her role as the troubled Lisa Rowe in Girl, Interrupted. Nicole Kidman’s best actress Oscar for The Hours now sits on her parents’ mantelpiece in Sydney, where neighbours apparently pass by for visits. Hollywood’s darling du jour, Jennifer Lawrence, keeps the award she won last year for her leading role in Silver Linings Playbook on top of her parents’ piano at home in Kentucky.
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资，把配置比重从两年前相对基准超配6%至8%调整至超配1%。
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
4. Mark Turner Quartet “Lathe of Heaven” (ECM) On his first proper album as a leader in 13 years, the tenor saxophonist Mark Turner favors slithery interplay with the trumpeter Avishai Cohen, and finds new purpose in post-bop protocols. There’s dry intrigue in his compositions, and supple exactitude in his rhythm team: Joe Martin on bass, Marcus Gilmore on drums.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
英国剑桥大学Judge商学院(Judge Business School)排名上升速度最快，今年上升19位，名列第29位，这得益于其在高管MBA排名中的出色表现（该学院今年首次参与此项排名）。华威商学院(Warwick Business School)重返榜单前20名（位列第19），该校去年未参加管理硕士排名。
A modular microarray imaging system for highly specific COVID-19 antibody testing
But the struggle for white identity is not just a political problem; it is about the “deep story” of feeling stuck while others move forward.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
East Asia's cinephiles won't have a local favorite to cheer during this year's foreign-language Academy Awards race after the Taiwan epic 'Warr
The quickest growth in executive pay on average came from the hotel and catering sectors, at 47.58%.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
1. “Timbuktu”(Abderrahmane Sissako)
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
FOYLE’S WAR (acorn.tv, Feb. 2) After nabbing the final three episodes of “Agatha Christie’s Poirot” last year, the streaming service Acorn TV scores another coup in the field of traditional British mysteries with the American premiere of this superior show’s ninth season. Starring Michael Kitchen as Christopher Foyle, a detective as honorable as he is shrewd, the series has morphed over the years from a provincial home-front cop show to a le Carré-like Cold War thriller. New episodes involve the Nuremberg trials and Britain’s role in Palestine.
A pair of post-mumblecore comedies about self-realization and its limits. Mr. Bujalski’s is a flawless screwball triangle (with Guy Pearce, Cobie Smulders and Kevin Corrigan as the sides) masquerading as an easygoing hangout with the oddballs of Austin, Tex. Ms. Piven surveys the darker territory of mental illness and daytime television. Thanks to Kristen Wiig’s astounding performance (as a lottery winner named Alice Klieg), “Welcome to Me” is a portrait of an American dreamer that is unsettling and inspiring in equal measure.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The film version of the popular television series "Legend of Sword and Fairy", also known as Chinese Paladin starts shooting in Zhejiang Province today.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Whenever I talk to people about the future, I'm struck by their belief that it is knowable. The impression I get is that most people imagine the future like a book ending: already written and readable if you can just steal a quick look at the last few pages. What they find difficult is accepting that the pages aren't written yet. The future hasn't happened, hasn't even been planned--and cannot be known because it doesn't exist.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
“Since these developments will not fade overnight, there is little hope for a trade revival in 2017,” says Mr Leering.
This habit can seriously hurt you in a work setting. If you’re one of those folks who believes that you do your best work at the last minute and put off projects or assignments until the day (or hour) before they’re due, you may not be aware of the impact your habit is having on your co-workers.If your last-minute rush requires others to work quickly, you will likely anger them, and you’ll be the first one blamed when a project fails or isn’t completed on time.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The swap is due largely to the major security breach at software company Adobe in October which affected tens of millions of users.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Homeowners in neighborhoods like the Grand Concourse in the Bronx or Elmhurst in Queens could enjoy new attention from buyers eager to find the next untapped market. “When have you heard talk about Kingsbridge in the Bronx?” asked Ms. Ramirez of Halstead. “The people who are smart are getting out there and buying it up at wonderful prices.”
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
1."The Little Kicks" in Seinfeld Almost Didn't Happen
6.You Spend Time Looking For Other Jobs
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
At tech start-up conferences, such as Slush in Helsinki in December, everyone was talking about experiences. The coming year is likely to see a wider adoption of virtual reality, which places the user in a digitally enhanced environment, and augmented reality, which overlays digital information on to the real world, creating new digital businesses.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Unless Charles Oakley successfully sues owner James Dolan, the highlight of the Knicks' 2016–17 season will be Kristaps Porzingis winning the Skills Challenge at All-Star Weekend.
Length-scale dependence of protein hydration-shell density
The annual national civil service exam kicked off last Sunday, and some recent hot topics - such as college graduates starting their own businesses and the Yutu (Jade Rabbit) lunar rover - appeared in the exam questions.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Warm greetings and best wishes for the New Year!致以热烈的祝贺和良好的祝福,新年快乐。
Consoles: Xbox One, Xbox 360
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Her mother Stephanie Boyden, 32, says Bobbi is a 'diva' who runs to the stage when her name is called - and screams when she has to leave.
That comes in spite of official figures released on Tuesday showing China’s exports had contracted for a second straight month in October, suggesting domestic demand is the main driver of price gains for producers.
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n. 授予物，补助金; 同意，给予